DELIVERY OF NUCLEIC ACID AND NANOPARTICLES
Design and synthesis of new materials that utilize constitutive endosomal uptake and processing mechanisms to improve the delivery and performance of small molecule and nucleic acid biotherapeutics are a major focus in the Thompson Lab. The bioresponsive carrier systems we prepare — e.g., lipids, lipopeptides, lipopolymers, polyrotaxanes, diblock copolymers, and host:guest pendant polymers—are designed to degrade upon internalization within endosomes to release their therapeutic cargo into the cytosol of target cells. These basic studies are directed toward elucidating the fundamental material properties that influence carrier system efficacy in human tissue culture, primary dendritic cells, and animal models of cancer (bladder, lung, breast, and pancreatic).
SELECTED PUBLICATIONS
“Development and In Vitro Characterization of Bladder Tumor Cell Targeted Lipid-Coated Polyplex for Dual Delivery of Plasmids and Small Molecules”, International Journal of Nanomedicine201914, 9547-9561.
“Development of Dihydrochalcone-functionalized Gold Nanoparticles for Augmented Antineoplastic Activity”, International Journal of Nanomedicine201813, 1917-1926.
“PLGA-PEG Nano-delivery System for Epigenetic Therapy”, Biomedicine & Pharmacotherapy 2017 90, 586-597.
“Targeting and Internalization of Liposomes by Bladder Tumor Cells Using a Fibronectin Attachment Protein-Derived Peptide-Lipopolymer Conjugate”, Bioconjugate Chemistry 2017 28, 1481-1490.
“Pluronic based b-Cyclodextrin Polyrotaxanes for Treatment of Niemann-Pick Type C Disease”, Scientific Reports 2017 7, 46737.
“Impact of Surfactant Treatment of Paclitaxel Nanocrystals on Biodistribution and Tumor Accumulation in Tumor-bearing Mice”, Journal of Controlled Release 2016 237, 168-176.
“Mechanistic Insight into Receptor-mediated Delivery of Cationic-β-Cyclodextrin:Hyaluronic Acid-Adamantane Host:Guest pDNA Nanoparticles to CD44+ Cells”, Molecular Pharmaceutics 2016 13, 1176-1184.
“Structure-Property Relationship for siRNA Delivery Performance of Cationic 2-Hydroxypropyl-b-cyclodextrin: Poly(ethylene glycol)-Poly(propylene glycol)-Poly(ethylene glycol) Polyrotaxane Vectors”, Biomaterials 2016 84, 86-98.
“Efficient pDNA Delivery Using Cationic 2-Hydroxypropyl-β-Cyclodextrin Pluronic based Polyrotaxanes”, Macromolecular Bioscience 2016 16, 63-73. (journal cover)
“Decitabine Nanoconjugate Sensitizes Human Glioblastoma Cells to Temozolomide”, Molecular Pharmaceutics 2015 12, 1279-1288.